M\u0101ksl\u012bg\u0101s asaras ie\u0146em svar\u012bgu vietu saus\u0101s acs sindroma terapij\u0101. M\u0101ksl\u012bg\u0101s asaras var lietot k\u0101 patst\u0101v\u012bgu terapijas l\u012bdzekli, ja saus\u0101s acs sindroma saslim\u0161ana ir vieglas vai vid\u0113jas pak\u0101pes, vai kombin\u0101cij\u0101 ar citiem prepar\u0101tiem saus\u0101s acs sindroma smago gad\u012bjumu \u0101rst\u0113\u0161an\u0101.<\/p>\n
Past\u0101v pla\u0161a m\u0101ksl\u012bgo asaru prepar\u0101tu izv\u0113le, bet katrs produkts at\u0161\u0137iras p\u0113c sast\u0101va, t.i. da\u017e\u0101ds elektrol\u012btu daudzums un procentu\u0101ls saturs, ar da\u017e\u0101diem osmolarit\u0101tes un viskozit\u0101tes koeficientiem, ar vai bez konserventiem utt. (McDonald,<\/strong><\/em> 2007). Lai atrastu tie\u0161i Jums vajadz\u012bgo prepar\u0101tu s\u0101kotn\u0113ji ir j\u0101konsult\u0113jas ar redzes apr\u016bpes speci\u0101listu.<\/p>\n <\/p>\n M\u0101ksl\u012bgo asaru pamat\u012bpa\u0161\u012bbas:<\/p>\n Elektrol\u012btu sast\u0101vs.<\/u> M\u0101ksl\u012bgo asaru sast\u0101vam j\u0101b\u016bt l\u012bdz\u012bgam asaru elektrol\u012btu sast\u0101vam.<\/p>\n Osmolarit\u0101te.<\/u> Pacientiem ar saus\u0101s acs sindromu, asaru osmolarit\u0101te ir liel\u0101ka nek\u0101 veseliem pacientiem. P\u0113c b\u016bt\u012bbas m\u0101ksl\u012bgo asaru osmolarit\u0101tei j\u0101b\u016bt t\u0101dai pa\u0161ai k\u0101 vesel\u0101m asar\u0101m, bet p\u0113c da\u017eu p\u0113t\u012bjumu rezult\u0101tiem optim\u0101la izv\u0113le, kad m\u0101ksl\u012bgo asaru osmolarit\u0101te ir liel\u0101ka. Past\u0101v ar\u012b m\u0101ksl\u012bgo asaru produkti ar \u013coti augstu osmolarit\u0101ti, t.i. kolo\u012bdu osmolarit\u0101tes produkti jeb lielu mikromolekulu koncentr\u0101ciju produkti. \u0160\u0101da veid\u0101 m\u0101ksl\u012bgo asaru priek\u0161roc\u012bbas ir t\u0101das, ka samazin\u0101s boj\u0101to epit\u0113lija \u0161\u016bnu piet\u016bkums.<\/p>\n Viskozit\u0101te.<\/u> Augst\u0101ka asaru viskozit\u0101te pal\u012bdz asar\u0101m ilg\u0101k notur\u0113ties uz acs virsmas, t.i. padara asaru pl\u0113v\u012bti stabil\u0101ku, un pal\u012bdz aizsarg\u0101t acu virsmu. \u201cViskozit\u0101tes a\u0123enti, kas ir m\u0101ksl\u012bgo asaru sast\u0101v\u0101, ir karboksimetilceluloze, polivinilspirts, polietil\u0113nglikols, propil\u0113nglikols, hidroksipropil-guar\u0101ns un lip\u012bdi, ar\u012b tie, kas veido r\u012bc\u012bne\u013c\u013cu vai miner\u0101le\u013c\u013cu.\u201d Lip\u012bdi, kas ir m\u0101ksl\u012bgu asaru sast\u0101v\u0101 papildina lip\u012bdu sl\u0101ni un padara to biez\u0101ku, l\u012bdz ar to samazin\u0101s asaru iztvaiko\u0161ana no acs virsmas (Management and therapy of dry eye disease<\/em>,<\/em> 2007). Augstas viskozit\u0101tes a\u0123enti m\u0113dz izrais\u012bt att\u0113la krop\u013co\u0161anos. Pie vid\u0113ji smagas un vieglas saus\u0101s acs sindroma pak\u0101pes parasti izmanto zemas viskozit\u0101tes a\u0123entus, lai nepasliktin\u0101tu att\u0113la kvalit\u0101ti pacientiem, bet smagos saus\u0101s acs sindroma gad\u012bjumos noteikti j\u0101izmanto augstas viskozit\u0101tes a\u0123enti. Parasti augstas viskozit\u0101tes oftalmolo\u0123iskie prepar\u0101ti ir g\u0113li un \u017eelejas, kas ir lietojami uz nakti, lai dienas laik\u0101 nepasliktin\u0101tu redzes asumu un t\u0101d\u0113j\u0101di nerad\u012btu diskomfortu pacientam (Asbell<\/em>,<\/strong> 2006).<\/p>\n Konservantus izmanto, lai aptur\u0113tu bakt\u0113riju koloniju vairo\u0161anos m\u0101ksl\u012bgo asaru prepar\u0101tos, un t\u0101d\u0101 veid\u0101 pagarina \u0161\u0137idruma lieto\u0161anas laiku un to der\u012bguma termi\u0146u. Past\u0101v divu veidu konservanti: deter\u0123enti un oksidat\u012bvie konservanti.<\/p>\n M\u0101ksl\u012bg\u0101s asaras ar konservantiem parasti noz\u012bm\u0113 vieglas pak\u0101pes saus\u0101s acs sindroma gad\u012bjum\u0101 un ir lietojamas no \u010detr\u0101m l\u012bdz se\u0161\u0101m reiz\u0113m dien\u0101. Smagos saus\u0101s acs sindroma gad\u012bjumos un, ja ir nepiecie\u0161ams pilin\u0101t bie\u017e\u0101k, piem\u0113ram glaukomas pacientiem, tiek noz\u012bm\u0113ti bezkonservantu oftalmolo\u0123iskie prepar\u0101ti, kas nerada papildus risku konservantu negat\u012bv\u0101s ietekmes d\u0113\u013c (Management and therapy of dry eye disease<\/em>,<\/em> 2007).<\/p>\n Sader\u012bgu \u0161\u0137\u012bdumu sast\u0101v\u0101 ir mazas nejonisk\u0101s molekulas (piem\u0113ram, glicer\u012bns). \u0160\u012bs molekulas tiek iek\u0161\u0101 \u0161\u016bn\u0101 un palielina \u0161\u016bnas iek\u0161\u0113jo osmolarit\u0101ti, neizjaucot \u0161\u016bnu metabolismu. T\u0101d\u0113j\u0101di m\u0101ksl\u012bgo asaru prepar\u0101ti, kas satur sader\u012bgus \u0161\u0137\u012bdumus, var nodro\u0161in\u0101t aizsardz\u012bbu pret osmotisko stresu. Produktu sast\u0101v\u0101, kas satur sader\u012bgus \u0161\u0137\u012bdumus bie\u017ei vien ir 0,9% vai 1% glicer\u012bna (McDonald,<\/strong><\/em> 2007).<\/p>\n Bie\u017ei m\u0101ksl\u012bgo asaru sast\u0101vu papildina ar hialuronsk\u0101bi jeb n\u0101trija hialuron\u0101tu, kas ir viskoelast\u012bga substance, kurai piem\u012bt pretiekaisuma darb\u012bba. Pamatojoties uz da\u017eiem p\u0113t\u012bjumiem, m\u0101ksl\u012bg\u0101s asaras ar hialuronsk\u0101bi sast\u0101v\u0101 uzr\u0101da lab\u0101kus rezult\u0101tus pacientiem ar saus\u0101s acs sindromu nek\u0101 tad, ja bija lietotas m\u0101ksl\u012bg\u0101s asaras ar viskozit\u0101tes a\u0123entiem (hidroksipropilmetilceluloze). \u0160\u0101d\u0101 gad\u012bjum\u0101 pacienti nov\u0113roja saus\u0101s acs sindroma simptomu iev\u0113rojamu samazin\u0101\u0161anos. Savuk\u0101rt citi p\u0113t\u012bjumi pier\u0101da, ka n\u0101trija hialuron\u0101ts bija iev\u0113rojami maz\u0101k efekt\u012bvs nek\u0101 lok\u0101ls ciklospor\u012bns, kuru izmanto k\u0101 asaru pl\u0113ves stabiliz\u0113t\u0101ju. Ar\u012b Gobleta \u0161\u016bnu daudzums bija svar\u012bg\u0101ks faktors nek\u0101 hialuronsk\u0101bes esam\u012bba m\u0101ksl\u012bgu asaru sast\u0101v\u0101 (<\/strong>Moon,<\/strong><\/em> 2007).<\/p>\n M\u0101ksl\u012bgas asaras samazina saus\u0101s acs sindroma simptomus, bet nemazina iekaisuma procesu, kuru pavada saus\u0101s acs sindroms. T\u0101p\u0113c papildus noz\u012bm\u0113 pretiekaisuma terapiju, kas ietver kortikostero\u012bdus, tetracikl\u012bnus, ciklospor\u012bnus (Lemp, <\/em>2008).<\/p>\n Sader\u012bgi \u0161\u0137idrumi.<\/u> Ir svar\u012bgi, lai jonu koncentr\u0101cija \u0101rpus \u0161\u016bnas neat\u0161\u0137iras no jonu koncentr\u0101cijas \u0161\u016bnas iek\u0161pus\u0113. Osmotiskais stress rodas, ja molekulu un\/vai jonu koncentr\u0101cija \u0161\u016bn\u0101 at\u0161\u0137iras no t\u0101, kas atrodas \u0101rpus \u0161\u016bnas. Saus\u0101s acs sindroma gad\u012bjum\u0101 pacienta radzenes epit\u0113lijs tiek pak\u013cauts hiperosmol\u0101r\u0101m asar\u0101m un rodas osmotiskais disbalanss. Osmotiska stresa apst\u0101k\u013cos radzenes epit\u0113lija \u0161\u016bn\u0101m ir tieksme zaud\u0113t daudz \u016bdens. Lai kompens\u0113tu \u016bdens daudzuma izmai\u0146as, palielin\u0101s elektrol\u012btu koncentr\u0101cija \u0161\u016bnas iek\u0161pus\u0113, kas savuk\u0101rt var novest pie \u0161\u016bnu boj\u0101jumiem (McDonald,<\/strong><\/em> 2007).<\/p>\n","protected":false},"excerpt":{"rendered":" Daudziem pacientiem interes\u0113 un daudzi pacienti lieto acu mitrin\u0101t\u0101jus. Past\u0101v liela mitrino\u0161o prepar\u0101tu izv\u0113le, bet k\u0101 saprast, kas ir vajadz\u012bgs konkr\u0113t\u0101 gad\u012bjum\u0101.<\/p>\n","protected":false},"author":1,"featured_media":5869,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[6],"tags":[127],"class_list":["post-255","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ocular","tag-acu-mitrinasana"],"jetpack_featured_media_url":"https:\/\/mobileoptic.lv\/wp-content\/uploads\/2020\/06\/doctor-s-office-clinic-smiling-woman-treats-eye-young-man-using-eye-drops-cartoon-character-medical-worker-patient-flat-illustration_223337-633.jpg","jetpack_sharing_enabled":true,"jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/posts\/255","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/comments?post=255"}],"version-history":[{"count":2,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/posts\/255\/revisions"}],"predecessor-version":[{"id":5724,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/posts\/255\/revisions\/5724"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/media\/5869"}],"wp:attachment":[{"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/media?parent=255"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/categories?post=255"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mobileoptic.lv\/lv\/wp-json\/wp\/v2\/tags?post=255"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}